The long-term goal of this research is to elucidate the genes and metabolic pathways involved in the biosynthesis of phosphonic acid antibiotics and to explore the molecular diversity of natural products comprising this unusual class of bioactive compounds.The second project involves the development and application of genetic techniques for analysis of the methane-producing archaea.He is the author of more than 200 research articles and three books.In recognition of his scientific accomplishments, Silhavy was awarded an honorary Doctor of Sciences degree from his alma mater, Ferris State College (1982), and was elected Fellow of the American Academy of Microbiology (1994), the American Association for the Advancement of Science (2004), and the American Academy of Arts and Sciences (2005); he is a member of the National Academy of Sciences (2005) and an associate member of EMBO (2008).Finally, in the third section, an effort is undertaken to determine systems level mechanisms which dictate the coordinate regulation of hundreds of simultaneous regulatory events in response to major physiological and metabolic perturbations.crystalise, crystalize, crystallise, shed light on, sort out, crystallize, elucidate, illuminate, enlighten, straighten out, clear up, clear - make free from confusion or ambiguity; make clear; "Could you clarify these remarks?This research aims to characterize energy-conserving methanogenic metabolism and the mechanisms of archaeal gene regulation.
The first examines the metabolism of reduced phosphorus compounds, with particular emphasis on phosphonic acid antibiotics.
Silhavy is a bacterial geneticist who has made fundamental contributions to several different research fields.
He is best known for his work on protein secretion, membrane biogenesis, and signal transduction.
Using as a model system, his lab was the first to isolate signal sequence mutations, to identify a component of cellular protein secretion machinery and an integral membrane component of the outer membrane assembly machinery, and to identify and characterize a two-component regulatory system.
Current work in his lab is focused on the mechanisms of outer membrane biogenesis and the regulatory systems that sense and respond to envelope stress and trigger the developmental pathway that allows cells to survive starvation.